What is pargeverine?

Pargeverine is a chemical compound classified as an active ingredient , which belongs to the line of drugs with antispasmodic and spasmolytic properties, with a direct effect on the smooth muscle of the gastrointestinal system. (1)

What is pargeverine used for?

  • Pargeverine acts by relaxing the hollow smooth muscle fibers , also prevents visceral spasm and reverses hypoxia caused by spasm.   
  • It is used to treat: 
    • Painful spasms and hepatic colic .
    • Pharyngoesophageal dyskinesias, dysphagia, functional gastritis .
    • Pyloric spasms and duodenitis. 
    • Ulcer disease, associated with basic treatments.
    • Cholecystopathies and cholecystitis.
    • Sphincter of Oddi spasms and biliary dyskinesias.
    • Acute colitis , spasmodic colitis, sigmoiditis.
    • Constipation syndrome due to colonic hypermyotonus, renal and ureteral colic .
    • Ureteral and bladder spasms and cystitis.
    • Premenstrual tension, functional tubal spasm, and painful adnexitis.
    • As an aid in the treatment of dysmenorrhea .
    • Irritable bowel syndrome. (two)

Dosage and routes of administration of pargeverine

The presentations of pargeverine according to the trademark of the manufacturing laboratory, are generally in tablets or tablets that contain 10 mg pargeverine hydrochloride; vials containing pargeverine HCL 5 mg and drops solution . The administration is by oral or intramuscular route and the dosage by way of information can be as explained below:

  • Tablets: The recommended dose is 1 tablet every 8 hours a day, for adults and children over 12 years of age. 
  • Injectable solution: 1 vial every 24 hours. 
  • Solution drops: Adults and children over 12 years of age, 20 to 40 drops 3 or 5 times a day. 

What products contain pargeverin?

Some of the medicines that contain pargeverin are:

  • Plidan®
  • Plidan Compound®
  • Bebitex®
  • Viadil Composite®


  • Plidan® is the trademark of a medicine in the form of tablets, which uses pargeverine as the active ingredient.
  • It is indicated in the treatment of painful processes in the digestive tract.
  • For more information about this medicine, see What is plidan and what is it used for? .

Plidan Compound®

  • Plidan compound® is a synthetic medicine, which uses the combination of pargeverine hydrochloride 10 mg and lysine clonixinate , which comes in the form of tablets.
  • It is used to treat disorders of the digestive system .


  • Bebitex® is an antispasmodic medication in drops, which uses pargeverin as the active ingredient.
  • It is used for the treatment of spasms and pain of gastrointestinal , biliary, urinary tract and female genital tract origin.

Viadil Composite®

  • Compound Viadil® is a combined medication, which uses a mixture of two active ingredients that are pargeverine and metamizole magnesium. 
  • It is indicated to treat spasmodic and painful conditions of the bile ducts, as well as intestinal colic.

Pargeverine Side Effects

Data from clinical studies have indicated that the therapeutic action of pargeverine has caused in groups of patients some of the following adverse effects: 

  • Allergy manifestations due to patient contact with any component of the formula.
  • Urinary retention and constipation.
  • Blurred vision and dizziness. 
  • Tachycardia.
  • Headache , insomnia and drowsiness.
  • Dry mouth and throat.
  • In the case of injection, redness may appear in the area of ​​application.

Important: Generally, at therapeutic doses, pargeverine does not have side effects, but if any of them occur, please stop using it and consult your doctor .

Pargeverine Contraindications and Warnings

The use of pargeverine is contraindicated in the following cases: 

  • Patient hypersensitivity to any component of the formula.
  • Patients with glaucoma, prostatic hypertrophy and heart failure.
  • During the pregnancy period.
  • During breastfeeding .
  • In children under 12 years of age.

You should know: Before starting treatment with pargeverin, provide your doctor with all the information about your medical history .

Avoid if you have:

  • History of hypersensitivity to pargeverine.
  • Organic pyloric stenosis.


  • Pharmaceutical products such as pargeverine, must be administered with prescription or prescription.
  • Follow your doctor’s instructions during treatment with this drug.
  • Do not exceed recommended dose.
  • Inform your doctor if you are being medicated with other drugs for other pathologies.
  • Keep this product out of the reach of children.

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