Zyloprim: what is it and what is it used for?

What is zyloprim?

Zyloprim ® is the trademark of a pharmaceutically manufactured drug that uses allopurinol as an active ingredient , a chemical compound belonging to the line of drugs called xanthine oxidase inhibitors, with an effect on the excess production of uric acid in the body .

To be highlighted: This pharmaceutical product is manufactured by the company named Aspen Port Elizabeth (PTY) Limited and distributed in Mexico by Aspen México, S. de RL de CV (1)

What is zyloprim used for?

• Thanks to the mechanism of action of its active ingredient, zyloprim® acts on purine catabolism, reducing the production of uric acid by inhibiting xanthine oxidase, reducing the concentration of urate in plasma and urine (2) . This action favors the reduction of some ailments caused by excess levels of uric acid and urates, in conditions in which there have been deposits of these in the body.
• It is used to treat:
  • Gout attacks. (3)
  • uric acid lithiasis.
  • Acute uric acid nephropathy.
  • Neoplastic disease and myeloproliferative disease.
  • The overproduction of urates caused by certain enzymatic alterations.
  • Mixed recurrent renal lithiasis of calcium oxalate, in the presence of hyperuricosuria.
  • Lesch -Nyhan syndrome and some types of glycogenosis.
  • Intermediate-risk tumor lysis syndrome .
  • Enzymatic alterations of glucose-6-phosphatase.

Dosage and routes of administration of zyloprim

The presentation of zyloprim® is in a box with tablets containing allopurinol 100 mg or 300 mg. The administration is orally and the dosage as a reference can be as follows:

• Adults: 100 to 200 mg every 24 hours in mild cases; from 300 to 600 mg per day in cases of moderate severity and from 700 to 900 mg every 24 hours in severe cases.
• Children under 15 years of age: The recommended dose is 10 to 20 mg/kg/day, up to a maximum of 400 mg per day according to medical advice.

Side effects of zyloprim

Therapeutic treatment with zyloprim® may cause some of the following adverse reactions in a certain patient population:

• Possible allergic reactions due to contact with any component of the drug formula.
• Forunculus , agranulocytosis, aplastic anemia, thrombocytopenia.
• Diabetes mellitus, hyperlipemia.
• Coma, paralysis, ataxia, peripheral neuropathy, and paresthesia.
• Drowsiness, headache , dysgeusia, depression .
• Cataracts, visual impairment, maculopathy.
• Vomiting , nausea, high blood pressure, dizziness.
• Stevens-Johnson syndrome and toxic epidermal necrolysis.
• Male infertility, erectile dysfunction, gynecomastia.
• Skin rash, alopecia and change in hair color.

Important: If during treatment with this drug you as a patient observe any of these symptoms or another not included in the list, please stop using it and consult your doctor .

Contraindications and warnings of zyloprim

The use of zyloprim® is contraindicated in the following cases:

• Patient hypersensitivity to any of the components of the formula.
• Patients carrying the HLA-B*5801 allele.
• In people medicated for other pathologies without medical approval.
• During the pregnancy period.
• During breastfeeding .

You should know: Before starting treatment with zyloprim®, the patient must provide his doctor with all the information about his health history .

Avoid if you have:

• History of hypersensitivity to allopurinol.
• Medication for other pathologies.
• Severe liver or kidney damage.

Warnings:

• Pharmaceutical products such as zyloprim® must be administered with a prescription or prescription.
• In patients with impaired renal or hepatic function, a reduced dosage should be used.
• Follow your doctor’s instructions during treatment with this drug.
• The administration of this product makes the patient drowsy, so you should not drive vehicles or operate precision machinery.
• Keep this medicine out of the reach of children.