What is the alevian duo and what is it for?

Gas retention and intestinal hyperactivity can create problematic situations for people, sometimes associated withgastrointestinal diseases. The discomfort and pain can be such that they impede the day to day of the person.

Fortunately, there is a line of treatment with antiflatulent and antispasmodic medications such as alevian duo®, which is very useful to treat the associated symptoms and which we will talk about in the next article.

What is the alevian duo?

Alevian duo® is the trade name for the combination of two active ingredients: pinaverio bromideanddimethicone, synthesized by “Takeda” laboratories(1). It is used by gastroenterologists forits mechanism of antispasmodic and antiflatulent action, thus reducing uncomfortable and painful symptoms.

Alevianduo®comes as an oral administration capsule, each consisting of100 mg pinaverio and 300 mg dimethicone. The dose used is1 tablet, twice a day, 15 minutes before each meal, like breakfast.

Note: The alevian duo®is a comprehensive treatment with triple mechanism of action, being antispasmodic regulator of intestinal transit, reduces incoercible diarrhea and functional disorders associated with meteorism. (2)

What is the alevian duo for?

The alevian duo® has greatmedical utility to treat overactive colonand discomforts related to gas retention, as we will explain below:

1. Irritable bowel syndrome

Also known asnervous colitisand abbreviated as IBS. The pathophysiological mechanisms of irritable bowel syndrome are not yet fully elucidated, but it is known that it is a functional modification that leads tovisceral hyperalgesia and allodynia (perceiving a non-painful stimulus as if it were).

, constipation discomfort and pain.

Notable: Antispasmodics, such as alevian duo®, have been approved in Europe, Mexico, and Canada to treat IBS. (3)

2. Functional disorders of the bile ducts

These include biliary dyskinesia and stenosis, biliary movement disorders, and reduction in the diameter of the sphincter of Oddi(the opening that connects the gallbladder and pancreas with the small intestine), respectively. This causes accumulation of bile and pancreatic juice, generating intense pain.

You should know: People who undergo sphincterectomy can develop biliary dyskinesia, which is why the first line of symptomatic treatment includes drugs such as Pinaverium bromide, the active ingredient in alevian duo®. (4)

3. Functional Colopathies

, alevian duo® is highly useful as a treatment.

Note: Patients experience a reduction in symptoms such as abdominal pain or discomfort.

Side effects of alevian duo

The alevian duo® is poorly absorbed in the bloodstream and brain, so its adverse effects are infrequenttag. These are:

• Pain in the pit of the stomach (epigastralgia)
• nausea
• Threw up
• Constipation
• Dizziness
• dry mouth
• Headache.

Important : In case of presenting these reactions for long periods of time, suspend the use of the drug and see your doctor of preference .

Contraindications of the alevian duo

If you have any of the following conditions, please notify your physician prior to prescribingAlevian

• Known drug allergy.
• Peptic or duodenal ulcers.
• Ulcerative colitis.
• Esophagitis (the product can exacerbate the inflammatory picture).

You should know : The pharmacological information regarding the use of alevian duo® during pregnancy or lactation is inconclusive, so its use is not recommended. (5)

Key Findings

• The alevian duo® is the commercial name of the Combined product of Pinaverium Bromide and Dimethiconetag. It comes in capsules of 100 mg of bromide and 300 mg of dimethicone.
• The alevian duo® is used to Reduce intestinal and antiflatulent transit , indicated for gastrointestinal and biliary disorders, such as biliary dyskinesia and IBS.
• Bromide acts on calcium channels in smooth muscle, and dimethicone decreases gas bubble tension.
• Side effects of the alevian duo® are very rare, they include nausea, vomiting, constipation , dizziness, among other symptoms.
• alevian duo® should not be used if you have been diagnosed or suspected of having duodenal ulcers or oesophagitis .