Pain and swelling are some of the cardinal symptoms in many inflammatory diseases. Products such as non-steroidal anti-inflammatory drugs are very useful to reduce these symptoms.
In this sense we have dorixin®, which has shown efficacy in experimental studies. Next, we will talk about its use, contraindications and possible adverse reactions.
What is dorixin?
Dorixin is the trade nameof lysine clonixinate, a drug marketed bySiegfried Rhein®, S.A. de C.V. laboratories. (1). Its mechanism of actionis the same as that of other non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. (2)
Note: It should be noted that dorixin®comes in tablet form of 125 and 250 mg, with oral administration.
In addition, certain presentations such as dorixin flex®, combine lysine clonixinate with other active ingredients, such as cyclobenzaprine hydrochloride, to enhance the analgesic effects.
What is dorixin for?
Dorixin® is used asan analgesic, in a large number of pains or conditionsand there are studies that suggest that its effectiveness is similar to that of other analgesics, as we will see below:
1. Gynecological and urological pain
The aches andcramps associated with menstruation (known asdysmenorrhea) tend to be quite debilitating.
To highlight: To treat the frequency and intensity of symptoms, the combination of dorixin withL-butylhyoscine bromide has shown favorable results as a line of treatment. (3)
2. Orthopedic and general trauma pain
The pain produced by gonarthrosis (inflammation of the knee joint) and ankle Sprain , could be treated orally with dorixin®.
when treated with lysine clonixinate, with a dose of 125 mg, after a few days.
You should know: In the care of postoperative pain after general biliary surgery, dorixin® was shown to significantly reduce pain at rest , in a study published by the Spanish Pain Society in 1998. (6)
3. Odontalgia and periodontitis
Odontogenic pain is a frequent complaint in dentistry . Analgesics such as paracetamol or ibuprofen are generally used to reduce pain.
Note: A study published in the Journal of Health Sciences showed that the combination of paracetamol with the active principle of dorixin® is useful for relieving pain and postoperative inflammation , which usually occurs after dental surgery. (7)
4. Headache, ear pain and sinusitis
Since dorixin® inhibits cyclooxygenase (enzyme responsible for the conversion of arachidonic acid to proinflammatory molecules), it is useful for cases of pain with an inflammatory component .
To highlight: However, the use of other medications is preferred as the initial line of treatment.
Dorixin Side Effects
The risk of adverse reactions is greater with dorixin ® than with other NSAIDs, such as ibuprofen or diclofenac, therefore its use in humans is limited. Next, we will mention the most common:
- Peptic ulcer formation.
- Gastrointestinal disturbances, such as nausea and Vomiting .
- Hematological alterations, such as different types of anemia and decreased platelets.
- Organic lesions in liver, kidney and pancreas.
Important: In the event of any of the aforementioned side effects, it is necessary to discontinue the use of dorixin® and seek medical attention.
Dorixin Contraindications
Dorixin® should be avoided when used in patients with the following conditions, to avoid the risk of adverse reactions :
- Known hypersensitivity to dorixin® and its components.
- Pregnant and lactating women.
- Active peptic ulcer.
- Blood diseases.
- Hepatic or renal dysfunction.
- Diabetes mellitus.
You should know: Before starting treatment with dorixin®, it is advisable to inform the doctor about the health conditions that are suffered, thus avoiding unwanted reactions and to receive more information on the proper use of the drug.
Key Findings
- Dorixin® is a medication used in patients with pain and inflammation of gynecological, odontogenic, orthopedic or other causes.
- Dorixin® comes in 125 and 250 mg tablets, with oral route of administration.
- Among the most frequent adverse effects of dorixin® are those of the gastrointestinal and blood spheres, such as ulcerations or anemia.
- Before starting treatment with dorixin®, you need to be aware of the contraindications to avoid unwanted reactions.
University Professional in the area of Human Resources, Postgraduate in Occupational Health and Hygiene of the Work Environment, 14 years of experience in the area of health. Interested in topics of Psychology, Occupational Health, and General Medicine.