What is presistin?

Presistin® is a synthetic medicine that uses cisapride as an active ingredient, a chemical compound that belongs to the line of gastrointestinal prokinetic drugs, with localized effect on the smooth muscles of the digestive tract. (1)

To highlight: This drug is commercially manufactured by the pharmaceutical company namedLABORATORIOS MAVER S.A. de C.V. (2)

What is presistin for?

  • Thanks to the mechanism of action of its active ingredient, presistin®works as an agonist of serotonin receptorsand physiologically increases the release of acetylcholine in the myenteric plexus, being effective in the treatment ofthe balance of motility of the gastrointestinal tract(3)
  • It is used to treat:
    • Gastroesophageal reflux disease and gastroparesis of various etiologies. (4)
    • Idiopathic and chronicconstipationwith colonic hypomotility.
    • Intestinal pseudo-obstruction associated with motility alterations.
    • Impaired motor coordination in the digestive tract.
    • Esophagitis.

Dosage and routes of administration of presistin

The presentation of presistin® is usually in 10 mg tablets and in a 1 mg/ml suspensionin a 60 ml bottle. The administration of this medicine is orally and the dosage as a guide can be as follows:

  • Adults: 5 to 10 mg 2 to 4 times a day is recommended.
  • Children: With a weight between 25 and 50 kg, maximum 20 mg per day divided into 4 doses.

Presistin Side Effects

Clinical data indicate that treatment with presistin® may cause some of the following adverse effects in a certain patient population:

  • Hypersensitivity to any component of the formula.
  • Abdominal cramps and diarrhea .
  • Headache, vertigo, seizures and extrapyramidal effects.
  • Increased urinary frequency and heart rate.
  • Reversible abnormalities of liver function.
  • Hyperprolactinemia.

Important: If any of these symptoms appear during treatment with presistin®, please discontinue use and consult your doctor .

Contraindications and warnings of presistin

The use of presistin® is contraindicated in the following cases:

  • Hypersensitivity to any of the formula’s components.
  • In patients with known hypocalcaemia or hypomagnesaemia.
  • People with clinically significant bradycardias.
  • Children less than 2 months old.
  • During the first trimester of pregnancy or while Breastfeeding .
  • If you are being medicated with other drugs for other pathologies without the authorization of the treating physician.

You should know: This medication is of delicate use, so you must provide all the information about your medical history to your doctor, before starting treatment with this drug.

Avoid if you have:

  • History of hypersensitivity to cisapride.
  • History of cardiac disorders with prolongation of the QT interval.
  • Family history of congenital long QT syndrome.
  • History of kidney failure.
  • Severe dehydration, vomiting , eating disorders.
  • Cardiac arrhythmia.


  • This product should not be administered without prescription or prescription.
  • Follow your doctor’s instructions during treatment with cisapride.
  • Patients suspected of presenting risk factors for cardiac arrhythmias should be previously evaluated by a specialist physician.
  • Pharmaceutical products such as presistin® should be kept out of the reach of children.
  • Avoid self-medicating.

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