What is phenylephrine?

Phenylephrine is a type of active substance ofsympathomimetic amine (direct agonist of the sympathetic system) and vasoconstriction, which has the characteristic of being vasopressor, dilating and decongestant.

Note: Phenylephrine is applicable in different treatments indicated by a specific doctor, since its functions extend to various conditions or particular conditions.

What is phenylephrine for?

  • Phenylephrine is a vasoconstrictor (which promotes constriction in blood vessels) adrenergic agonist, that is, it has an effect similar to theadrenalineh ormone and balances peripheral resistance without having a direct activity before the central nervous system.
  • It is used to treat:
    • Hypotension during anesthesia.
    • Hypotension from depressant drugs.
    • Nasal congestion.
    • Influenza. (1)
    • Cold.

Dosage and routes of administration of phenylephrine

Phenylephrine hydrochloride comes as aform of intravenous, intramuscular, or subcutaneous solutions for injection, always from a trained medical professional. The doses in which it is usually administered in adults are the following for informational purposes:

  • Intravenous: One injection of 0.2 mg to a maximum of 0.5 mg.
  • Intramuscular or subcutaneous: Injections ranging from 1 mg to 5 mg maximum. The initial doses indicated are always 2 mg.

To highlight: Phenylephrine can take from 10 minutes to 15 minutes to fully act on the system when they are intramuscular or subcutaneous injections, but they have a long duration of 1 to 2 hours.

What products contain phenylephrine?

Some of the medicines that contain phenylephrine are:

  • Phenylephrine®.
  • Laritol D®.
  • It will feel®.
  • Agrifen®


  • Phenylephrin® is a vasoconstriction medication , marketed by Rinque Pharma laboratories . (two)
  • It is administered by solution intravenously, subcutaneously, intramuscularly and also injectable glucose solution.
  • It is composed of phenylephrine hydrochloride and is also a sterile vehicle for sodium chloride. (3)

Laritol D®

  • Laritol D® is a commercial product manufactured by Maver Products Laboratories . (4)
  • It is made with the active compounds of phenylephrine and loratadine , adding Antihistamine Characteristics , ideal for Runny Nose and rhinitis.
  • It is in the form of a syrup with an oral administration route .

It will feel®

  • Sensibit® is a commercial medicine made by Liomont Laboratories . (5)
  • It is a drug manufactured with the diversity of metabolites that are phenylephrine, paracetamol and loratadine.
  • It works to Relieve the Flu, Runny Nose, Headaches, and also excess mucus or nasal congestion.


  • agrifen® is a commercial product from the PiSA laboratories line . (6)
  • It is a mixture of the metabolites of paracetamol, chlorphenamine, phenylephrine and caffeine, being antipyretic and also an effective analgesic .
  • It becomes fully absorbed in about 30 minutes to 1 hour and works for nasal congestion and fever .
  • For more information about this medicine, see Agrifen: What is it and what is it used for? .

Phenylephrine Side Effects

Phenylephrine is a well-tolerated substance in the body, however, like many drugs, it can cause moderate or peculiar adverse reactionstag. Among the side effects of phenylephrine are the following:

Important: If you experience any of the effects mentioned above or one not included in the list, stop using the medication and consult a health professional.

Contraindications and warnings of phenylephrine

Due to certain unwanted interactions, phenylephrine is contraindicated in a certain number of patients, who may react negatively to treatment with this drug. Therefore, it is not recommended in the following cases:

  • Pediatric patients.
  • Hypersensitivity to the medical formula.
  • Increased blood pressure.
  • Hyperthyroidism
  • Renal insufficiency.
  • Heart failure.
  • Pregnancy.

Avoid if you have:

  • Diabetes mellitus.
  • constant tachycardia.
  • Arrhythmias.
  • Closed-angle glaucoma.


  • Phenylephrine should always be administered under the supervision of a specialist doctor.
  • Keep this medicine out of the reach of children.
  • This drug should be kept in a dry and cool place.
  • Phenylephrine should not be used in patients with cerebrovascular disease or recent brain hemorrhage.

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