What is nalixone?

Nalixone® is the registered trademark of a pharmaceutically manufactured medicine that uses nalidixic acid (1) and phenazopyridine as active ingredients , two chemical substances belonging to the line of medicines with local antibiotic and analgesic effect, with action on certain urinary infections . caused by bacteria .

To highlight: This pharmaceutical product is made by the company called Laboratorios Química Son’s CA de CV (2)

What is nalixone used for?

  • Thanks to the joint action mechanism of its active ingredients, nalixone® has a bactericidal property to eliminate a large number of bacterial microorganisms, in addition to having a local analgesic effect to relieve ailments caused by an infection in the urinary tract.
  • It is used to treat:
    • Acute and painful urinary tract infections caused by gram- negative microorganisms sensitive to nalidixic acid and associated symptoms ( Klebsiella, Enterobacter, Escherichia coli and most Proteus strains ). (3)

Dosage and routes of administration of nalixone

Nalixone® is sold in a box with 20 tablets, where each tablet contains nalidixic acid 500 mg, 50 mg of phenazopyridine hydrochloride. The administration is orally and the dosage as a reference can be as follows:

  • Adults: Dose of 2 tablets every 6 hours per day.
  • Children: Dose of 55 mg/kg of weight per day or 1.5 to 2 g per day, in several doses.

side effects of nalixone

Therapeutic treatment with nalixone® may cause some of the following adverse reactions in a certain patient population:

  • Possible allergic reactions in patients sensitive to the components of the formula.
  • Itching, hives and angioedema.
  • Eosinophilia, joint stiffness.
  • Toxic psychoses or mild seizures.
  • Drowsiness, weakness, headache, paresthesias and vertigo.
  • Subjective and reversible visual disturbances.
  • Photosensitivity and change in color perception.
  • Increased intracranial pressure, with bulging of the anterior fontanelle.
  • Dyspepsia, abdominal pain , nausea, vomiting and diarrhea .
  • Leukopenia or hemolytic anemia .

Important: If any of these symptoms appear or another that is not included in the list, please stop its consumption and consult your doctor .

Contraindications and warnings of nalixone

The use of nalixone® is contraindicated in the following cases:

  • Patient hypersensitivity to any of the components of the formula or antibiotics from the quinolone group.
  • Patients with kidney failure.
  • Liver failure.
  • In children under 1 year of age.
  • During the first trimester of pregnancy.
  • During the breastfeeding period .

You should know: Before starting treatment with this drug, provide all the information regarding your health history to your doctor.

Avoid if you have:

  • History of hypersensitivity to the components of the formula or to quinolones.
  • History of seizures.
  • History of severe kidney or liver damage.


  • Products such as nalixone® must be administered with a prescription or prescription.
  • Follow your doctor’s instructions during treatment with this drug.
  • This product must be administered under medical supervision.
  • Nalidixic acid may increase the effects of oral anticoagulants.
  • Keep this medicine out of the reach of children.

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