What is levodropropizine?

Levodropropizine is a synthetic medication classified as an active principle that is used as an antitussive, which causes an anesthetic effect and temporarily inhibits the functioning of the afferent pathways that regulate the cough reflex .

What is levodropropizine used for?

  • Levodropropizine has an effect against cough, which is produced by blocking the release of neuropeptides and inflammatory substances, preventing the activation of C fibers in the trachea, bronchi, and lungs, where the cough originates. (1)
  • It is used to treat: 
    • Symptoms of dry cough from various causes. (two)

Dosage and routes of administration of levodropropizine

The presentation of levodropropizine is in 60 mg tablets in boxes of 10 or 20 units. It is also sold as syrup in 30, 60, 120 and 200 ml bottles and 60 mg/ml drops, in 15 or 30 ml bottles. The route of administration of this medicine in all its presentations is oral and the dose for information may be as follows:

  • Tablets: For adults only, one 6 mg tablet 3 times a day.
  • Syrup: Children from 2 to 12 years old, 1 ml/kg 3 times a day; adults 10 ml of syrup, 3 times a day.
  • Drops: Adults and children over 12 years of age, 20 drops every 8 hours. Children over 2 years of age, 1 mg/kg of weight every 8 hours without exceeding the daily dose of 3 mg/kg.

What products contain levodropropizine?

Some of the medicines that contain levodropropizine are:

  • Levotuss®
  • Levocof®
  • Tossevo®
  • Zyplo®


  • Levotuss® is a medication in the form of a syrup whose active ingredient is levodropropizine, an antitussive compound.
  • It is indicated to treat unproductive forms of cough , such as irritative cough or nervous cough in adults and children over 2 years of age.


  • Levocof® has levodropropizine as its active principle, in the form of a 100 ml solution.
  • It is used in the symptomatic treatment of cough.


  • Tossevo® is a medication in the form of a 6 mg/ml syrup based on levodropropizine, which is the active principle.
  • It is indicated for the treatment of different forms of cough in children over 2 years of age and adults, such as irritative cough or nervous cough.


  • The main component of zyplo® is levodropropizine, which comes as a tablet, syrup, and solution drops.
  • It is indicated for the symptomatic treatment of dry , irritative cough and smoker’s cough.

side effects of levodropropizine

Levodropropizine may cause some of the following adverse reactions in certain patients : 

  • Possible allergic reactions due to contact with any component of the formula.
  • Nausea and vomiting.
  • Dyspepsia, abdominal discomfort or diarrhea .
  • Drowsiness and mental confusion. 
  • Numbness, dizziness, or headache.

Important: If any of these symptoms or any other not on this list appear during treatment with levodropropizine, stop using it and consult your doctor.

Contraindications and warnings of levodropropizine

Levodropropizine is contraindicated in the following cases:

  • Hypersensitivity to any of the formula’s components.
  • During pregnancy or lactation .
  • Patients with bronchial hypersecretion.
  • Children under 2 years.

To highlight: Before starting treatment with levodropropizine, it is advisable to provide your doctor with all the information about your health history.

Avoid if you have:

  • Reduced mucociliary function.
  • Severe liver or kidney insufficiency.
  • That drive vehicles or operate machinery.


  • Use only 14 days maximum in adults and 7 days in children.
  • This pharmaceutical product should be taken outside of meals.
  • Levodropropizine should be kept out of the reach of children.
  • Antitussive medicines should be stored in a dry and cool place.

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