Kativil: What is it and what is it for?

What is kativil?

It is anutritional supplement, which facilitates the entryof long-chain fatty acidsinto cellular organelles where oxidation and energy production occur.

Components

Its main source iscarnitine, an amino acid whose function isto transport fatty acids into the mitochondria. Carnitine is also known asL-carnitine or levocarnitine.

Presentations and dosage

The paediatric presentation of kativil is inoral solution 1g/10ml. The adult presentation is a1g/10ml oral solution.

The recommended dose according to the “Spilva Guide of pharmaceutical specialties”, is as follows: 1 or 2 g / day in divided doses. Children 50 – 100 mg/kg/day.

Note: For the proper dosage, the specialist should be consulted.

What is the kativil indicated for?

Thanks to the composition of kativil (levocarnitine), it is indicated when there is a deficiencyof this amino acid in the body. Below we present the conditions in which this medication is prescribed.

Brain abnormalities

One of the main functions of L-Carnitine is the transport of long-chain essential fatty acids , such as alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid ( Dha), to mitochondrial cells. , including those of the central nervous system. This function helps tomaintain the patient’s cognitive functions correctly.

Note: Carnitine deficiency in the diet of pregnant women can cause autism in the baby.

levocarnitine deficiency

If you suffer from hyperammonemia, hepatomegaly, cardiomyopathy , arrhythmias, muscle weakness, neurological problems, seizures, or developmental delay, you may be deficient in L-Carnitine.

Note: In the “MSD Manual, version for professionals” , it describes the effects of deficiency of this cellular component in the body. (1)

Hepatotoxicity

Hepatotoxicity is a form of liver disease , caused by ingestion of chemical or organic compoundstag. Long-term therapy with anticonvulsant drugs such as valproic acid is associated withlow levels of levocarnitine.

L-Carnitine is recommended for prophylactic treatment in patients under treatment with valproic acid who present increased risk of hepatotoxicity.

Important: Insufficient carnitine could contribute to the detrimental effects of valproic acid on the liver.

A study indicates that the use of L Carnitine has been included as an oral supplement in patients receiving valproic acid treatment, based on the discovery of their deficiency of this amino acid. (two)

Complement in dialysis treatment

In those cases where there are patients with Prolonged Hemodialysis Treatment , due to renal deficiency, the insufficiency of L Carnitine must be compensated through its oral or parenteral consumption.

Note: A study on “Benefits of L-carnitine supplementation in pediatric hemodialysis patients. Report of cases” , indicates the improvement of hemodialysis patients, with treatment of this compound. (3)

Kativil contraindications

In some people, due to previous pathologies, the use of this medication is contraindicated. Here we mention the most common:

Allergy to components

There are patients sensitive to this compoundtag. If during the use of kativil you noticeallergic forms such as skin rash, itching or hives, swelling of the face, lips or tongue, stop using it and consult your doctor immediately.

hypoglycemia

In diabetic patients who are under insulin treatment , there may be a risk of causing possible hypoglycemia.

severe kidney failure

Special care must be taken, in patients suffering from severe renal insufficiency who are on prolonged dialysis treatment, in the administration of large doses of L-Carnitine.

Adverse reactions of kativil

The use of Kativil, through its main component, levocarnitine, can present certain annoying reactions in some patients , among which are mentioned:

Gastrointestinal disorders

The adverse effects caused by L Carnitine are rare, andgastrointestinal discomforts such as vomiting, nausea, diarrhea and cramps in the abdomen may occur. This is indicated by a doctoral thesis on “Influence of the administration of L Carnitine on cardiovascular risk factors in a geriatric population”. (4)

Increased blood clotting time

In patients treated with anticoagulant drugs , the prothrombin time, that is, the time it takes for a clot to form, can be increased, with the risk of prolonging excessive bleeding.

body stink

The use of L Carnitine can cause in certain patients, the fishy odor syndrome, called “trimethylaminuria”, due to the defect in the hepatic oxidation of trimethylamine that comes from the metabolism of levocarnitine.

Key Findings

• Kativil is a medication that provides an important amino acid such as levocarnitine.
• The use of this supplement is due to carnitine deficiency in the body.
• It must be done under medical prescription.
• It can have side effects and contraindications, so it is necessary to administer it under medical supervision.