What is geslutin?

Geslutin® is the trade name of a medicine thatuses progesterone as a natural active ingredient, a substance that can be included within the line of hormone replacement drugs witheffect mainly on the female reproductive system(1)

To highlight: This pharmaceutical product is manufactured in the United States by the company calledCatalent Pharma Solutions, LLC.

What is geslutin for?

  • Geslutin®possesses the properties of natural progesterone, specifically as a gestagen, antiestrogen, antiandrogen and antialdosterone, which helpsregulate and stabilize reproductive and fertility cycles in women.
  • It is used to treat:
    • Secondary infertility due to luteal deficiency.
    • Regulation of menstruation. (3)
    • Benign mastopathies.
    • Recurrent abortion.
    • Preterm birth.
    • Hormone replacement in the pre- and postmenopausal period and in women deprived of ovaries.
    • Premenstrual syndrome.
    • Supplementation in the luteal phase, during spontaneous or induced cycles.

Dosage and routes of administration of geslutin

Geslutin® is soldas capsules or pearls, 100 or 200 mgwith micronized progesterone. The administrationis oralor vaginal and the dosage as a referential may be as follows:

  • Progesterone insufficiency: Doses of 200 to 300 mg of progesterone per day, divided into two doses preferably in the morning and before bedtime outside meals.
  • Luteal insufficiency (PMS, benign mastopathy, menstrual irregularities, premenopause): 2 to 3 capsules of 100 mg per day, as directed by your doctor.
  • Menopausal treatment: 2 x 100 mg capsules or 1 x 200 mg/day capsule taken at bedtime as directed by your doctor.
  • Vaginally in the replacement of progesterone in women with ovarian deprivation:1 pearl of 100 mg vaginally according to medical indications.
  • Vaginally in the threat of abortion or in the prevention of repeated miscarriage due to luteal insufficiency: 2 to 4 pearls of 100 mg or 1 to 2 pearls of 200 mg vaginally / day according to medical indications.

Side effects of geslutin

Clinical data indicate that geslutin®therapy may cause in a certain population of women, some of the following side effects:

  • Possible allergic reactions due to the patient’s contact with any component of the formula.
  • Probable alteration of menstrual rhythm.
  • Presence of fatigue, nausea, headache andmigraine.
  • It can causedepressionand changes in libido.
  • Occasional drowsiness or vertigo.

Important: If any of these or other unlisted symptoms occur during treatment with geslutin®, pleasediscontinue use and consult your doctor.

Contraindications and warnings of geslutin

The use of geslutin®is contraindicatedin the following cases:

  • Hypersensitivity to any of the components of the formula.
  • Undiagnosed vaginal bleeding.
  • Ongoing or incomplete abortion.
  • Patients with known breast or genital tract cancer.
  • Dubin-Johnson syndrome.
  • During the breastfeedingperiod.

You should know: Before starting treatment with this medication, give all the information about your health history to yourdoctor.

Avoid it if you have:

  • History of hypersensitivity to any of the components of geslutin®.
  • Severe liver disease.
  • Deep vein thrombosis or active pulmonary embolism.


  • Pharmacological products such as geslutin®, must be administered with a prescription or prescription.
  • The administration of this medicine as a supplement therapy during the period of pregnancy, is at the discretion of the attending physician.
  • Caution should be exercised in patients suffering fromfluid retention.
  • Do not exceed the recommended dose and follow your doctor’s directions.
  • Keep this product out of reach of children.

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