What is the clavipen?

Clavipen®is the registered brand name of a medicine, which uses the combination of two active ingredients, amoxicillin(1) and clavulanic acid(2), two chemical compounds belonging to the line of medicineswith antibiotic effecton those bacteria that cause infections.

To highlight: This pharmaceutical product is made by the company namedBRULUAGSA, S.A. DE C.V. (3)

What is the clavipen for?

  • Thanks to its active ingredients, clavipen®becomes a powerful broad-spectrum bactericidal drug, because clavulanic acid and amoxicillin become sensitive to germs producing ß-lactamases. This actionfavors the elimination of bacteria that cause infectionsin the respiratory tract and in other areas of the body.
  • It is used to treat:
    • Upper respiratory tract infectionssuch astonsillitis,sinusitis, pharyngitis and otitis media.
    • Lower respiratory tract infections such as acute and chronicbronchitis, lobar pneumonia, and bronchopneumonia.
    • Cystitis.
    • Pyelonephritis.
    • Urethritis of gonococcal origin.
    • Osteomyelitis.
    • Skinand soft tissue infections.
    • Intra-abdominal sepsis.
    • In general, to eliminateGram-positiveandGram-negative, aerobic and susceptible anaerobic bacteria or strains.

Dosage and routes of administration of clavipen

Clavipen® is sold in a box with amoxicillin trihydrate tablets equivalent to 500 mg of amoxicillin and potassium clavulanate equivalent to 125 mg of clavulanic acid and in a bottle with suspensionin different concentrations. In both cases, the administrationis orally and the dosage for information may be as follows:

  • Tablets: Adults one tablet every 8 hours for 7 to 10 days of treatment according to medical indication and in children the dosage will be calculated based on body weight.
  • Suspension 125 mg/5 ml:For children of 14 kg, 4 ml every 8 hours; from 13 kg, 3.5 ml every 8 hours; between 11 and 12 kg, 3.0 ml every 8 hours; between 9 and 10 kg, 2.5 ml every 8 hours; between 7 and 8 kg, 2.0 ml every 8 hours and from 5 to 6 kg, 1.5 ml every 8 hours and in all cases for a period between 7 and 10 days of continuous treatment.

Clavipen Side Effects

The therapeutic treatment with clavipen® can cause some of the following adverse effects in certain types of patients :

  • Possible appearance of allergic reactions due to contact with any component of the formula.
  • Nausea, vomiting and diarrhea .
  • Alterations in liver function.
  • Hematological alterations, drug fever and acute interstitial nephritis.
  • Pseudomembranous colitis.
  • Leukopenia, neutropenia and thrombocytosis.

Important: If the appearance of any of these symptoms or another not included in the list occurs, please stop using it and consult your doctor .

Clavipen contraindications and warnings

The use of clavipen® is contraindicated in any of the following circumstances:

  • Hypersensitivity to any of the components of this medication or to Penicillins .
  • People with a creatinine clearance of less than 30 ml/minute.
  • Patients with cross-sensitivity to other β-lactam antibiotics, such as cephalosporins.

You should know: Provide all the information about your health historyto your doctor, before starting treatment with Clavipen®.

Avoid if you have:

  • History of hypersensitivity to penicillins or clavulanic acid.
  • History of cholestatic jaundice or hepatic dysfunction induced by amoxicillin or clavulanic acid.


  • Pharmaceutical products such as clavipen®, must be administered with a prescription or prescription.
  • Although this medicine represents a low risk during pregnancy or breastfeeding, its administration in these cases should be supervised by a doctor.
  • This drug should be administered with caution, in patients with evidence of liver dysfunction.
  • Keep this medicine out of the reach of children.
  • Store this product in a cool, dry place.

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