What is ampigrin?

Ampigrin is a combined synthetic medicine, which contains the active ingredient sampicillin®, metamizole sodium, guaifenesin,lidocaine hydrochloride and chlorpheniramine that place it in the line of medicines with antibiotic effect, which is used to treat patients with upper respiratory infections.

To highlight: This pharmaceutical product is made by the company called Productos Farmacéuticos COLLINS, S. A. de C. V. (1)

What is ampigrin for?

  • Ampigrin®mainly has bactericidal antibiotic action, eliminating infection-causing bacteria in the respiratory tract and the rest of the ingredients in the formula treat the symptoms associated with theserespiratory diseases.
  • It is used to treat:
    • Upper respiratory infections such as pharyngitis, sinusitisbronchitis, pneumonia andtonsillitis, caused by bacteria sensitive to the antibiotic compound(2) that present with symptoms that include malaise, pain, fever, nasal congestion and sneezing. (3)
    • InfluenzaA viruses, including H2N2, H1N1, and H3N2.
    • Otitis.
    • Infectious processes caused by penicillin-sensitive bacteria.

Ampigrin dosage and routes of administration

The ampigrin presentations areboxed with 1 or 3 vials of ampoules of 250 mg and 500 mg of sodium ampicillin® powder, to prepare solution for injection of 1 or 3 ampoules with 3 ml of diluent. The route of administrationis intramuscular and the dose for information purposes may be as follows:

  • Adults: Apply a prepared vial of ampoule every 8 hours for one to two days.
  • Children: Apply a vial prepared every 8 hours for one to two days in the pediatric presentation.

Ampigrin Side Effects

Treatment with ampigrin® can cause in certain patients some of the following Adverse reactions :

  • Possible allergic reactions by contact with any of the components of the formula.
  • Possible nausea, dizziness, hypotension.
  • bronchospasm and tachycardia.
  • In exceptional cases, leukopenia, agranulocytosis or thrombocytopenia may occur.
  • In isolated cases, excessive sweating and chills may appear.
  • Dry mouth, nose and throat.

Important: If you experience any of these symptoms or one not included in the list during treatment with ampigrin®, please discontinue use and notify your doctor.

Contraindications and warnings of ampigrin

The use of ampigrin® is contraindicated in the following circumstances:

  • Hypersensitivity to any of the formula’s components.
  • In patients with asthma by analgesics.
  • In patients with impaired bone marrow function.
  • In people with hypotension or circulatory instability.
  • Patients with narrow angle glaucoma.
  • In patients with stenosing peptic ulcer and pyloroduodenal obstruction.
  • In people with hyperthyroidism and cardiovascular disease.
  • During pregnancy and lactation .

You should know: Provide all the information about your health history to your doctor, before starting treatment with ampigrin®.

Avoid if you have:

  • History of kidney disease.
  • History of hypersensitivity to any of the components of the drug.
  • Medication with monoamine oxidase inhibitors.


  • Ampigrin should not be confused with ampigrin®® PFC, as the latter contains completely different components and the medical indications are different.
  • Products such as ampigrin® must be administered with a prescription or medical prescription.
  • Clinical data indicates that ampigrin® cannot be combined with alcohol, tricyclic antidepressants, barbiturates, or other central Nervous System depressants .
  • This medication should be kept out of the reach of children.
  • Keep stored in a cool dry place.

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